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anti-palk (y1278) rabbit mab  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc anti-palk (y1278) rabbit mab
    Anti Palk (Y1278) Rabbit Mab, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/anti-palk (y1278) rabbit mab/product/Cell Signaling Technology Inc
    Average 90 stars, based on 1 article reviews
    anti-palk (y1278) rabbit mab - by Bioz Stars, 2026-02
    90/100 stars

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    Neuroblastoma cells expressing wild-type ALK (NB-1 and IMR-32) and mutated ALK (SK-N-SH) or with no detectable ALK expression (SK-N-AS) were treated with increasing doses of CDX-0125-TEI, a control IgG1 antibody conjugated with TEI (IgG1-TEI), or the free payload (NMS-P528). Titration of CDX-0125-TEI induced cytotoxic activity in all ALK-expressing models, with IC50 values in the picomolar range and independent of ALK mutation status or number of cell surface ALK receptors. By contrast, no measurable IC50 value could be derived in the ALK-negative cell line SK-N-AS. Free NMS-P528 elicited complete cell killing at sub-picomolar concentrations in all cell lines tested. Quoted IC50 and ALK expression values reflect calculated means and SEM (n = 3) from at least three independent experiments.

    Journal: Science translational medicine

    Article Title: An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma

    doi: 10.1126/scitranslmed.aau9732

    Figure Lengend Snippet: Neuroblastoma cells expressing wild-type ALK (NB-1 and IMR-32) and mutated ALK (SK-N-SH) or with no detectable ALK expression (SK-N-AS) were treated with increasing doses of CDX-0125-TEI, a control IgG1 antibody conjugated with TEI (IgG1-TEI), or the free payload (NMS-P528). Titration of CDX-0125-TEI induced cytotoxic activity in all ALK-expressing models, with IC50 values in the picomolar range and independent of ALK mutation status or number of cell surface ALK receptors. By contrast, no measurable IC50 value could be derived in the ALK-negative cell line SK-N-AS. Free NMS-P528 elicited complete cell killing at sub-picomolar concentrations in all cell lines tested. Quoted IC50 and ALK expression values reflect calculated means and SEM (n = 3) from at least three independent experiments.

    Article Snippet: Upon immobilization onto polyvinylidene difluoride (PVDF) membranes, proteins were labeled using one of the following antibodies: phosphorylated ALK (Y1278), total ALK, cleaved caspase-3, and GAPDH (Cell Signaling Technology).

    Techniques: Expressing, Titration, Activity Assay, Mutagenesis, Derivative Assay